The Myotones project aims to analyse the basic biomechanical properties of the skeletal muscles in a non-invasive way, using a small, handheld device. With MyotonPRO, changes in human resting muscle (tone, elasticity and rigidity) caused by lack of gravity are measured and evaluated for astronauts onboard the International Space Station (ISS). The technology has already been successfully applied in bed rest studies; moreover, the device has already proven to be suitable for taking measurements under microgravity during parabolic flights.